کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2480421 1556184 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spray-by-spray in situ cross-linking alginate hydrogels delivering a tea tree oil microemulsion
ترجمه فارسی عنوان
هیدروژل های آلژینات در محل تلاقی اسپری در محل تزریق روغن مایع روغن چای
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

In this paper we propose an in situ forming ionically cross-linked alginate (Alg) hydrogel delivering a Tea Tree Oil microemulsion (MeTTO) and potentially useful as an advanced dressing for infected wounds. Alg hydrogels were prepared by a spray-by-spray deposition method with the aim to minimize the discomforts during application. From pseudoternary phase diagrams, it was found that proper combination of TTO, water, polysorbate 80 and ethanol gave stable spherical MeTTO with good antimicrobial activity. On this basis, MeTTO at 20% TTO was selected for further inclusion in an Alg hydrogel prepared by alternating sprays of Alg/MeTTO and calcium chloride solutions. Homogeneous dispersion of MeTTO inside cross-linked Alg was assessed by different macroscopic and microscopic methods demonstrating the superior propensity of MeTTO to be integrated in the water-based hydrogel as compared to TTO. Antimicrobial effect of Alg/MeTTO hydrogels on Escherichia Coli strains was remarkable, highlighting the potential of the system as bioactive wound dressing.

Figure optionsDownload high-quality image (157 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 66, 23 January 2015, Pages 20–28
نویسندگان
, , , , , , , , , ,