کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2481753 1556267 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determination of factors controlling the particle size in nanoemulsions using Artificial Neural Networks
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Determination of factors controlling the particle size in nanoemulsions using Artificial Neural Networks
چکیده انگلیسی

The purpose of this study was to use Artificial Neural Networks (ANNs) in identifying factors, in addition to surfactant and internal phase content, that influence the particle size of nanoemulsions. The phase diagram and rheometric characteristics of a nanoemulsion system containing polysorbate 80, ethanol, medium chain triglycerides and normal saline loaded with budesonide were investigated. The particle size of samples of various compositions prepared using different rates and amounts of applied energy was measured. Data, divided into training, test and validation sets, were modelled by ANNs. The developed model was assessed and found to be of high quality. The model was then used to explore the effect of composition and processing factors on particle size of the nanoemulsion preparation. The study demonstrates the potential of ANNs in identifying critical parameters controlling preparation for this system, with the total amount of applied energy during preparation found to be the dominant factor in controlling the final particle size.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 35, Issues 1–2, 2 September 2008, Pages 42–51
نویسندگان
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