کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2481856 | 1556282 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of erythrocytes on the hepatic distribution kinetics of urea and thiourea
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
The role of erythrocyte on the hepatic distribution kinetics of urea and thiourea was investigated in the in situ isolated perfused rat liver. Perfusion experiments were conducted using Krebs-bicarbonate buffer delivered via the portal vein in a single pass mode at a total flow rate of 15 ml/min. With urea, superimposable unimodal effluent curves were obtained in the presence and absence of erythrocytes, indicating that its distribution kinetics is not affected by erythrocytes. With thiourea, effluent curves were unimodal in the absence of erythrocytes but bimodal in the presence of erythrocytes. The maximum frequency output at the first peak increased from 0.017 ± 0.002 to 0.042 ± 0.006 sâ1 with an increase in the bolus hematocrit from 0.40 to 0.75, indicating that some thiourea fraction is retained by the erythrocytes on transit through the liver. Although the fractional output associated with the first peak was very similar (11.9% versus 11.5%), whether the perfusate contained unlabelled thiourea or not, this fraction was reduced from 17 to 5% with a decrease in the incubation time before injection from 30 min to 40 s. However, there was no evidence for a capacity limitation; a 30-min period of pre-incubation of either radiolabelled thiourea alone or combined with a high concentration of unlabelled thiourea had minimal effect on effluent profiles.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 31, Issues 3â4, July 2007, Pages 180-189
Journal: European Journal of Pharmaceutical Sciences - Volume 31, Issues 3â4, July 2007, Pages 180-189
نویسندگان
Selma Sahin, Malcolm Rowland,