کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2481973 1556283 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Investigation of an artificial intelligence technology—Model trees: Novel applications for an immediate release tablet formulation database
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Investigation of an artificial intelligence technology—Model trees: Novel applications for an immediate release tablet formulation database
چکیده انگلیسی

This study has investigated an artificial intelligence technology – model trees – as a modelling tool applied to an immediate release tablet formulation database. The modelling performance was compared with artificial neural networks that have been well established and widely applied in the pharmaceutical product formulation fields. The predictability of generated models was validated on unseen data and judged by correlation coefficient R2. Output from the model tree analyses produced multivariate linear equations which predicted tablet tensile strength, disintegration time, and drug dissolution profiles of similar quality to neural network models. However, additional and valuable knowledge hidden in the formulation database was extracted from these equations. It is concluded that, as a transparent technology, model trees are useful tools to formulators.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 31, Issue 2, June 2007, Pages 137–144
نویسندگان
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