کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2482543 1556300 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Simultaneous quantitation of five active principles in a pharmaceutical preparation: Development and validation of a near infrared spectroscopic method
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Simultaneous quantitation of five active principles in a pharmaceutical preparation: Development and validation of a near infrared spectroscopic method
چکیده انگلیسی

A near infrared spectroscopic method for the simultaneous determination of the active principles paracetamol, ascorbic acid, dextrometorphan hydrobromide, caffeine and chlorpheniramine maleate in a pharmaceutical preparation was developed. The five active principles are quantified using a partial least-squares regression method (PLS1). The proposed method is applicable over a wide analyte concentration range (0.04–6.50 wt.%), so it requires careful selection of the calibration set. Also, there is the difficulty of ensuring thorough homogenization of the product. The method was validated in accordance with the ICH standard and the EMEA validation guidelines for NIR spectroscopy by determining its selectivity, linearity, accuracy, precision and robustness. Based on the results, it is an effective alternative to existing choices (HPLC and redox titrimetry) for the same purpose.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 27, Issues 2–3, February 2006, Pages 280–286
نویسندگان
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