کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2482622 | 1556286 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
New MultiPEG-conjugated theophylline derivatives: Synthesis and pharmacological evaluations
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
The successful conjugation of active theophylline molecules to two new multifunctional high-molecular weight poly(ethylene glycol) derivatives (MultiPEG) and their pharmacokinetic evaluations are reported. The drug loading was increased up to six times in comparison with commercial PEG of the same molecular weight. A clear increase of the time of persistence within the body and a concomitant improvement of the overall pharmacokinetic properties of those prodrugs were also observed. These studies sustain the use of these new PEG-based polymeric supports as a valuable alternative for an effective drug delivery system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 30, Issues 3–4, March 2007, Pages 343–350
Journal: European Journal of Pharmaceutical Sciences - Volume 30, Issues 3–4, March 2007, Pages 343–350
نویسندگان
Marina Zacchigna, Gabriella Di Luca, Francesca Cateni, Venerando Maurich, Maurizio Ballico, Gian Maria Bonora, Sara Drioli,