Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs

The reaction of p-bromoanilino acetohydrazide(ll) with aromaticaldehydes in alcohol yielded 2-[4-bromo aniline] N-substituted benzylidine hydrazides (llla-lllj), which in presence of yellow mercuric oxide and iodine in DMF, yielded corresponding 4-bromo[(N-5-substituted 1,3,4 oxadiazole-2-yl)methyl]aniline (IVa-IVj). Structures of the compounds synthesized were confirmed by IR, 1HNMR and MASS spectroscopic analysis. The newly synthesized compounds were screened for antibacterial, antifungal and anti-inflammatory activities. Some of the compounds showed remarkable antibacterial, antifungal and anti-inflammatory activities.