کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2492799 1115118 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hypocholesterolemia: A major risk factor for developing pulmonary tuberculosis?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Hypocholesterolemia: A major risk factor for developing pulmonary tuberculosis?
چکیده انگلیسی

SummaryAlthough one-third of the world’s population is infected by Mycobacterium tuberculosis, only approximately 10% will develop the overt clinical disease due to a yet undefined risk factor. We hypothesize that hypocholesterolemia might constitute such a factor, because: (a) cholesterol is an important molecule for the good functioning of an immune system, and is necessary for macrophages to uptake and engulf mycobacteria, (b) tuberculous patients often have hypocholesterolemia, in comparison with the general population and household contacts, (c) cholesterol has a beneficial effect against pulmonary tuberculosis, since a cholesterol-rich diet accelerates the bacteriological sterilization of sputum, and (d) many conditions traditionally considered major risk factors for tuberculosis are accompanied by hypocholesterolemia. If this hypothesis proves to be true, cholesterol might be given to hypocholesterolemic subjects who are at high risk for developing pulmonary tuberculosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 66, Issue 6, 2006, Pages 1227–1230
نویسندگان
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