کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2493227 1556633 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pertussis toxin modulates microglia and T cell profile to protect experimental autoimmune encephalomyelitis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Pertussis toxin modulates microglia and T cell profile to protect experimental autoimmune encephalomyelitis
چکیده انگلیسی


• PTx reduces clinical deficits in EAE.
• PTx mitigates demyelination by reducing lymphocyte infiltration and microglia activation.
• The effects of PTx are subunit- and dose-dependent.
• PTx modulates T cell profile by increasing Th and Treg.

Pertussis toxin (PTx) has various effects in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This study was designed to explore the protective effects of PTx of different doses and subunits. EAE model was induced with myelin oligodendrocyte glycoprotein (MOG35–55, 200 ug) plus complete Freund's adjuvant in 6–7 week-old female C57BL/6 mice. PTx reduced clinical deficits of EAE by 91.3%. This reduction in clinical deficits was achieved by attenuating demyelination by 75.5%. Furthermore, PTx reduced the lymphocyte infiltration, deactivated microglia activation and changed T cell profile by increasing T helper (type 1 and 2) and T regulatory cells.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 81, June 2014, Pages 1–5
نویسندگان
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