Phenylpiperazine derivatives with selectivity for dopamine D3 receptors modulate cocaine self-administration in rats

► We tested the effect of three D3R compounds on responding for cocaine and sucrose. ► WC10, WC26 and WC44 reduced responding for cocaine and sucrose. ► WC26 and WC44 increased latency to respond for cocaine but not sucrose. ► WC10 and WC44 reduced responding for several doses of cocaine. ► Results suggest that motivation for cocaine is reduced by D3R compounds.