Spike-timing dependent plasticity in striatal interneurons

Basal ganglia, an ensemble of interconnected subcortical nuclei, are involved in adaptive motor planning and procedural learning. Striatum, the primary input nucleus of basal ganglia, extracts the pertinent cortical and thalamic information from background noise in relation with the environmental stimuli and motivation. The striatum comprises different neuronal populations: the GABAergic striatal output neurons, three classes of GABAergic interneurons and the cholinergic cells. Striatal interneurons exert a powerful control of striatal output neuron excitability and therefore shape the cortico-basal ganglia information processing. Besides output neurons, striatal interneurons also receive directly cortical information and are able to adapt their behavior depending on the level of cortical and striatal activation. In this review, we focus on the corticostriatal long-term synaptic efficacy changes occurring in interneurons, and especially the spike-timing dependent plasticity (STDP), as a Hebbian synaptic learning rule. Combined with the striatal local interactions between interneurons and output neurons, we will consider the functional consequences of the interneuron plasticity on the striatal output.This article is part of a Special Issue entitled ‘Synaptic Plasticity & Interneurons’.

Research highlights
► Striatum, the main input nucleus of basal ganglia, is involved in procedural learning.
► Striatal interneurons control corticostriatal information processing.
► We review the spike-timing dependent plasticity (STDP) in striatal interneurons.
► It exists a cell-specificity of STDP among striatal neuronal subtypes.
► We discuss about the synergy of corticostriatal STDPs on the striatal output.