کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2494294 1556661 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TGF-β as a promising option in the treatment of multiple sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
TGF-β as a promising option in the treatment of multiple sclerosis
چکیده انگلیسی

Transforming growth factor-β (TGF-β) is a potent regulatory cytokine with diverse effects on hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain tolerance via the regulation of lymphocyte proliferation, differentiation, and survival. Among T cells, CD4+CD25+FOXP3+ T regs contain the main source of TGF-β that suppresses immune responses in inflammatory sites. Defects in TGF-β1 expression or its signaling in T cells correlate with the onset of several autoimmune diseases. Thus, understanding the function and regulation of TGF-β during immune responses offers therapeutic promise for the control of autoimmune diseases such as multiple sclerosis. However, the main mechanism by which TGF-β exerts its protective effects on the experimental model of multiple sclerosis remains to be elucidated. Paradoxically, TGF-β1 also acts as a pro-inflammatory cytokine and induces interleukin 17-producing pathogenic T helper cells (Th IL-17 cells) synergistically during an inflammatory response in which interleukin 6 is produced. In this review, we will describe the regulatory and therapeutic effects of TGF-β in multiple sclerosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 56, Issues 6–7, May–June 2009, Pages 929–936
نویسندگان
, ,