کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2494308 1556661 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Downregulation of LPR1 at the blood–brain barrier in streptozotocin-induced diabetic mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Downregulation of LPR1 at the blood–brain barrier in streptozotocin-induced diabetic mice
چکیده انگلیسی

Deposition of amyloid-β peptide (Aβ) in the diabetic brain is poorly understood. Low-density lipoprotein receptor related protein 1(LRP1) at the blood–brain barrier (BBB) is critical for regulation of Aβ homeostasis in the brain. In this study, we used streptozotocin-induced diabetic mice to observe the expression of LRP1 at the BBB by Western blot and immunocytochemical analysis, and to study in vivo brain-to-blood efflux transport of 125I-Aβ1–40 using brain clearance studies. In the diabetic mice with hyperglycemia (>16.0 mmol/l) at 6 weeks, LRP1 expression at the BBB was significantly downregulated; no significant changes of LRP1 levels were found at 1 and 3 weeks after diabetes induction. The data of brain clearance studies for Aβ showed significant decrease in LRP1-dependent transport of Aβ across the BBB at 6 weeks after diabetes induction, while no significant changes of LRP1-dependent transport of Aβ across the BBB at 1 or 3 weeks after diabetes induction were apparent. We conclude that the downregulation of LRP1 at the BBB contributes to cerebral Aβ deposition in diabetes mellitus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 56, Issues 6–7, May–June 2009, Pages 1054–1059
نویسندگان
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