کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2494651 1115573 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fine-tuning serotonin2c receptor function in the brain: Molecular and functional implications
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Fine-tuning serotonin2c receptor function in the brain: Molecular and functional implications
چکیده انگلیسی

The serotonin2C receptor (5-HT2CR) is a member of the serotonin2 family of 7-transmembrane-spanning (7-TMS) receptors, which possesses unique molecular and pharmacological properties such as constitutive activity and RNA editing. The 5-HT2CR is widely expressed within the central nervous system, where is thought to play a major role in the regulation of neuronal network excitability. In keeping with its ability to modulate dopamine (DA) neuron function in the brain, the 5-HT2CR is currently considered as a major target for improved treatments of neuropsychiatric disorders related to DA neuron dysfunction, such as depression, schizophrenia, Parkinson's disease or drug addiction.The aim of this review is to provide an update of the functional status of the central 5-HT2CR, covering molecular, cellular, anatomical, biochemical and behavioral aspects to highlight its distinctive regulatory properties, the emerging functional significance of constitutive activity and RNA editing in vivo, and the therapeutic potential of inverse agonism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 55, Issue 6, November 2008, Pages 969–976
نویسندگان
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