کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2494684 1115575 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms of regulation for interleukin-1β in neurodegenerative disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Mechanisms of regulation for interleukin-1β in neurodegenerative disease
چکیده انگلیسی

The interleukin-1 family of cytokines are central to the pathology of acute and chronic diseases of the central nervous system. We describe current evidence on the transcriptional and post-transcriptional regulation of interleukin-1β production, secretion and activity in the brain. Regarding the induction of protein synthesis, the possible involvement of Toll like receptor-4 is discussed including evidence that ischemic brain damage is reduced in Toll like receptor-4 knockout mice. The post-translational involvement of the P2X7-receptor and caspase-1 in the processing and release of active IL-1β is also considered, as is evidence suggesting a possible extracellular cleavage of pro-IL-1β by neutrophil derived proteases. We provide some fresh perspectives on how interleukin-1β may be regulated and how these mechanisms could be targeted in disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 52, Issue 8, June 2007, Pages 1563–1569
نویسندگان
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