کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2495129 | 1115597 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of ketamine on acute somatic nociception in wild-type and N-methyl-d-aspartate (NMDA) receptor É1 subunit knockout mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of ketamine on acute somatic nociception in wild-type and N-methyl-d-aspartate (NMDA) receptor É1 subunit knockout mice Effects of ketamine on acute somatic nociception in wild-type and N-methyl-d-aspartate (NMDA) receptor É1 subunit knockout mice](/preview/png/2495129.png)
چکیده انگلیسی
Although the properties of ketamine appear to be well characterized, there is a lot of ambiguity in the literature regarding its analgesic effects. After careful selection of proper experimental conditions and drug doses, we systematically characterized the effects of systemic ketamine on acute somatic nociception in mice and examined the role of the NMDA receptor É1 subunit in mediating its analgesia. Intraperitoneal administration of ketamine was not analgesic in any of the phasic pain assays (thermal, mechanical, electrical) applied to C57BL/6 (wild-type) and NMDA receptor É1 subunit knockout (mutant) mice. Surprisingly, rather than being analgesic for thermal nociception, ketamine showed pronociceptive properties in case of low-intensity heat stimulation in wild-type mice. In the formalin test (tonic pain), ketamine significantly reduced phase 2 nociceptive behavior in both wild-type and mutant mice. These data indicate that in wild-type mice ketamine has no analgesic effect on phasic pain in normal somatic tissues, but alleviates tonic pain after inflammation. Such analgesic spectrum of ketamine can be fully explained by its NMDA receptor antagonist properties. The results for the mutant mice suggest that the É1 subunit of the NMDA receptor does not mediate the analgesic effects of ketamine in tonic pain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 50, Issue 6, May 2006, Pages 741-747
Journal: Neuropharmacology - Volume 50, Issue 6, May 2006, Pages 741-747
نویسندگان
Andrey B. Petrenko, Tomohiro Yamakura, Ahmed R. Askalany, Tatsuro Kohno, Kenji Sakimura, Hiroshi Baba,