کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2495268 | 1115606 | 2007 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Targeting the cholinergic system as a therapeutic strategy for the treatment of pain Targeting the cholinergic system as a therapeutic strategy for the treatment of pain](/preview/png/2495268.png)
Acetylcholine mediates its effects through both the nicotinic acetylcholine receptors (ligand-gated ion channels) and the G protein-coupled muscarinic receptors. It plays pivotal roles in a diverse array of physiological processes and its activity is controlled through enzymatic degradation by acetylcholinesterase. The effects of receptor agonists and enzyme inhibitors, collectively termed cholinomimetics, in antinociception/analgesia are well established. These compounds successfully inhibit pain signaling in both humans and animals and are efficacious in a number of different preclinical and clinical pain models, suggesting a broad therapeutic potential. In this review we examine and discuss the evidence for the therapeutic exploitation of the cholinergic system as an approach to treat pain.
Journal: Neuropharmacology - Volume 53, Issue 2, August 2007, Pages 197–206