Serotonin modulation of cell excitability and of [3H]GABA and [3H]d-aspartate efflux in primary cultures of rat cortical neurons

These findings suggest that 5-HT inhibits GABA release through 5-HT1A receptors and exerts a dual modulation on glutamate release, mostly facilitatory (through 5-HT3 receptors) but also inhibitory (through 5-HT1D/B receptors), leading to a prevalently positive modulation of the excitatory signal by amino acid neurotransmitter containing neurons.