کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2495400 | 1115617 | 2006 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Chronic low-dose administration of nicotine facilitates recovery and synaptic change after focal ischemia in rats Chronic low-dose administration of nicotine facilitates recovery and synaptic change after focal ischemia in rats](/preview/png/2495400.png)
The current study examines the effects of chronic administration of nicotine on motor behavior after focal stroke in rats. Animals were trained in a tray-reaching task for 2 weeks and then they were divided into: (1) control + saline (2) control + nicotine (3) stroke + saline, and (4) stroke + nicotine groups. Lesions were produced by devascularization of the surface blood vessels of the sensorimotor cortex contralateral to the forepaw used for reaching. Forty-eight hours after the lesions, and for a total of 12 days, animals received two daily injections of either nicotine (0.3 mg/kg) or saline (0.9%). Animals were tested in a motor battery 1 week after the lesions and every other week for a total of 7 weeks. Pyramidal cells in forelimb and cingulate areas were then examined for dendritic length and branching using a Golgi–Cox procedure. Behavioral results demonstrated that by the end of the testing stroke + nicotine animals showed significant behavioral improvement relative to stroke + saline animals. Stroke + nicotine animals showed an increase in dendritic length and branching in pyramidal cells of the forelimb and cingulate areas. The results suggest that the behavioral enhancement in the stroke + nicotine group might be attributable to the enhanced dendritic growth in residual cortical motor regions.
Journal: Neuropharmacology - Volume 50, Issue 7, June 2006, Pages 777–787