کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2497482 1116205 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of Cimicifuga racemosa extract on liver morphology and hepatic function indices
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Effects of Cimicifuga racemosa extract on liver morphology and hepatic function indices
چکیده انگلیسی

Cimicifuga racemosa (black cohosh) is a herbaceous perennial plant, that has been traditionally used for a variety of ailments (dyspepsia, climacteric complaints, muscular rheumatisms, menstrual cramps). From laboratory and clinical studies, black cohosh seems to have a relatively good safety profile, even if a number of case reports of hepatotoxicity were a matter of recent concern.AimA number of case reports indicated that C. racemosa could induce hepatotoxicity. We evaluated the effects of black cohosh extract on liver morphology, and on levels of various hepatic function indices in rats.MethodsWistar rats received 300 mg/kg/day of C. racemosa extract by gavage, for 30 days. Biochemical analysis of serum was conducted by an automated, random-access clinical chemistry analyzer. Liver samples were used for hystomorphological and immunohistochemical examination, for the detection of apoptosis (TUNEL assay), and for the determination of GSH level (spectrophotometrical analysis).ResultsC. racemosa extract does not affect liver morphology and hepatic function indices, in rats.ConclusionsOn the basis of experimental data, the use of 300 mg/kg/day of black cohosh appears quite safe in rats. Nevertheless, in humans the safety of C. racemosa should be further monitored, in terms of patient-related factors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 15, Issue 11, November 2008, Pages 1021–1024
نویسندگان
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