کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2497957 1116245 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Centella asiatica water extract inhibits iPLA2 and cPLA2 activities in rat cerebellum
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Centella asiatica water extract inhibits iPLA2 and cPLA2 activities in rat cerebellum
چکیده انگلیسی

Centella asiatica (L.) Urb an is distributed widely in South America and Asia and is known as a therapeutic agent in folk medicine, capable of improving memory and treating several neurological disorders. Asiaticoside is one of the compounds found in C. asiatica leaves that is suggested to be responsible for its pharmacological potential. Phospholipase A2 (PLA2) is a group of enzymes that has abnormal activity in the central nervous system in some neuropsychiatric diseases. In this work, the asiaticoside present in C. asiatica water extract was quantified by HPLC analysis. We also evaluated the activity of subtypes of PLA2 in cerebellar samples from rats after C. asiatica water extract treatment using a radioenzymatic assay. Asiaticoside was the major compound (84%) found in Centella water extract. We found a dose-dependent inhibitory effect of C. asiatica water extract on the activity of Ca2+-independent PLA2 (iPLA2) and cytosolic PLA2 (cPLA2). The inhibition of these enzymes in the brain suggests that C. asiatica may be useful to treat conditions associated with increased PLA2 activity in the brain, such as epilepsy, stroke, multiple sclerosis and other neuropsychiatric disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 15, Issue 10, 17 October 2008, Pages 896–900
نویسندگان
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