کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2498129 | 1116262 | 2007 | 5 صفحه PDF | دانلود رایگان |
Effects of Thymol on the spontaneous contractile activity (SCA) have been found in in vitro experiments with circular smooth-muscle strips (SMAs) from guinea pig stomach and vena portae. Thymol was found to possess an agonistic effect on the α1-, α2- and β-adrenergic receptors. Its spasmolytic effect is registered at doses higher than 10−6 M.Thymol in a dose of 10−4 M inhibits 100% the SCA of the SMAs and reduces the excitatory effect of 10−5 M ACH to 35%.It is assumed that Thymol has an analgesic effect through its action on the α2-adrenergic receptors of the nerve cells. By influencing the β-adrenergic receptors in the adipose cells, it is possible to induce increased synthesis of fatty acids and glycerol, which is a prerequisite for increased heat release.
Journal: Phytomedicine - Volume 14, Issue 1, 10 January 2007, Pages 65–69