کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2498868 1556835 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The ameliorative effect of propolis against methoxychlor induced ovarian toxicity in rat
ترجمه فارسی عنوان
اثر متقابل پروپولیس در برابر سمیت تخمدان ناشی از متاکسی کلل در موش صحرایی
کلمات کلیدی
متیو سایکلر، پروپولیس فولیکول های تخمدان، هورمون های استروئیدی، آسیب اکسیداتیو
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی

A study was designed to evaluate ameliorative effect of propolis against methoxychlor (MXC) induced ovarian toxicity in rat. The organochlorine pesticide (MXC) is a known endocrine disruptor with estrogenic, anti-estrogenic, and anti-androgenic properties. To investigate whether chronic exposure to MXC could cause ovarian dysfunction, two groups of Sprague–Dawley adult female rats were exposed to MXC alone in a dose of 200 mg/kg, twice/weekly, orally or MXC dose as previous plus propolis in a dose of 200 mg/l/day, in drinking water for 10 months. Another two groups of rat were given corn oil (control) or propolis. Multiple reproductive parameters, ovarian weight, serum hormone levels, ovarian oxidative status and ovarian morphology were examined. In MXC-exposed group, there is a significant decrease in body and ovarian weight vs. control. MXC decreases serum estradiol and progesterone levels. A significant increase in the levels of lipid peroxidation was obtained while a significant decrease of the total antioxidant was recorded. Ovarian histopathology showed primary, secondary and vesicular follicles displaying an atretic morphology. Increase in the ovarian surface epithelium height accompanied with vacuolated, pyknotic oocytes were obtained. The previous toxic effects were neutralized by the administration of propolis in MXC + propolis group. The present results suggest that propolis may be effective in decreasing of MXC-induced ovarian toxicity in rat.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Toxicologic Pathology - Volume 66, Issues 9–10, December 2014, Pages 415–421
نویسندگان
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