کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2498947 | 1116482 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: C/EBPα down-regulation is associated with reduced hepatic cellular viability during hypoxia in vitro and in vivo C/EBPα down-regulation is associated with reduced hepatic cellular viability during hypoxia in vitro and in vivo](/preview/png/2498947.png)
C/EBPα transcription factor is a key regulator in liver biology and was preliminarily shown to be down-regulated in hypoxic primary rat hepatocytes. The aim of this study was to explore the possible association between C/EBPα expression level and hepatocyte viability in both the in-vitro cultured hypoxic rat primary hepatocytes and two models of acute liver hypoxia induced by carbon tetrachloride or Fas antibody. C/EBPα mRNA was significantly down-regulated under hypoxic conditions both in vitro and in vivo, which was paralleled by a similar decrease in hepatocyte viability and partially reversed by 3D matrix and dexamethasone. These results suggested that C/EBPα down-regulation may be one mechanism of reduced hepatocyte viability in these settings.
Journal: Experimental and Toxicologic Pathology - Volume 63, Issue 4, May 2011, Pages 307–310