کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2499008 1116487 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Subcutaneous leiomyosarcoma in an adrenomedullin heterozygous mouse
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Subcutaneous leiomyosarcoma in an adrenomedullin heterozygous mouse
چکیده انگلیسی

The present study reports a case of a 5-month-old female adrenomedullin (AM) heterozygous (+/−) mouse that presented a mass of leiomyosarcoma found in the right shoulder girdle region. The neoplastic mass extended to the sternal region and showed hemorrhages, congestion and necrotic foci. The excised tumor with a diameter of 2.5 cm was firm, ill-demarcated and had focally infiltrated the surrounding muscles. The cut surface was homogeneously whitish with multi-focal reddish lesions. Microscopically, the tumor composed of variable fascicles of spindle-shaped cells with pleomorphic and cigar-shaped nuclei. The nuclei were round and elongated. Metastasis of tumor cell to skeletal muscle was frequently observed. Immunohistochemically, desmin, vimentin and α-smooth muscle actin (α-SMA) were demonstrated in neoplastic cells but tumor cells were negative for cytokeratin (CK) and S-100. Based on gross finding, microscopical examination and immunohistochemistry, the present case was diagnosed as a subcutaneous leiomyosarcoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Toxicologic Pathology - Volume 62, Issue 3, May 2010, Pages 221–225
نویسندگان
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