کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2499350 | 1116504 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Growth-related changes of parameters of the methylation cycle and jejunal aminopeptidase M in the rat
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
During development from juvenility to adulthood, rats displayed constant vitamin B12, decreasing folic acid and increasing homocysteine levels in blood plasma parallel to decreasing aminopeptidase M activities in the jejunum. The rising homocysteine level with advancing age implies growing metabolic stress and may be seen as cause for the increase of the number of cleft lip alveolus palate at pregnancies in higher age. Similarly, additional morphologic changes of the villi and crypta were regarded to reflect age-related adaptation of the digestive tract. Thus, the rat model is interesting for human-relevant studies of metabolic diseases or fetal anomalies, as in man these parameters develop likewise with increasing age. Sufficient supply of B vitamins is an important factor for a normal course of pregnancy, healthy offsprings and physiologic blood parameters and is essential to a stable methylation cycle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Toxicologic Pathology - Volume 59, Issue 5, 17 March 2008, Pages 291-295
Journal: Experimental and Toxicologic Pathology - Volume 59, Issue 5, 17 March 2008, Pages 291-295
نویسندگان
Jens Weingärtner, Sergej Maile, Jochen Fanghänel, Peter Proff, Tomasz Gedrange,