کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2499815 1556844 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats
چکیده انگلیسی

BackgroundTobacco use is associated with a high incidence of skin necrosis after surgery. The ideal timing for the cessation of tobacco use before plastic surgery has not, however, been precisely determined. The aim of this work was to define the ideal duration of nicotine withdrawal prior to random-pattern skin flap surgery in rats.MethodsGroups of 11 animals were subcutaneously injected with saline or nicotine (2 mg/kg) twice a day and subjected to random-pattern skin flap surgery according to the following protocol: Group I: continuously injected with saline 4 weeks before and 1 week after the surgery; Group II: injected with nicotine for 4 weeks until the day of the surgery; Group III: injected with nicotine for 4 weeks until one day before the surgery; Group IV: injected with nicotine for 4 weeks until 5 days before the surgery; Group V: injected with nicotine for 4 weeks until 10 days before the surgery; Group VI: continuously injected with nicotine for 4 weeks before and 1 week after the surgery. McFARLANE skin flaps were performed on the dorsal skin, and the rats were sacrificed 1 week after the surgery.ResultsThe necrotic area was smaller in group I (8.85 cm2) than in group II (12.15 cm2), III (12.88 cm2) and VI (14.84 cm2) (ANOVA p<0.0001). There was no difference between groups I, IV (10.13 cm2) and V (9.27 cm2).ConclusionsIn conclusion, 5 days before surgery was considered the ideal time for nicotine withdrawal in this experimental model.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Toxicologic Pathology - Volume 60, Issue 6, 18 September 2008, Pages 449–452
نویسندگان
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