کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2499822 1556844 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of dolomite oral exposure in Wistar rats during organogenesis period of pregnancy
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Effect of dolomite oral exposure in Wistar rats during organogenesis period of pregnancy
چکیده انگلیسی

The potential of oral exposure to dolomite, a natural product that contains calcium and magnesium, to initiate teratogenesis was analyzed in Wistar rats. Animals received dolomite oral dosages of 500 and 1500 mg/kg during the period of gestation from day 6–15 post conceptionem (p.c.). Maternal, embryo and fetal toxicity were evaluated. Dolomite exposure did not produce maternal toxicity assessed by clinical observations, body weight gain, hematology parameters and relative organs weight. Signs of embryo-fetal toxicity were not observed. Skeletal malformations and visceral variations were similar in control and dolomite-treated groups. On the other hand, slight increase was observed in fetal body weight in the dolomite-treated group. Treatment with dolomite resulted in significantly decreased incidences of unossified xiphisternum, incomplete ossification of xiphisternum and sternebrae. These effects could be caused by a beneficial influence of calcium and magnesium salts present in dolomite on ossification process. In conclusion, in this study we found that the oral exposure to rats of up to 1500 mg/kg of dolomite during organogenesis did not induce significant maternal and embryo-fetal toxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Toxicologic Pathology - Volume 60, Issue 6, 18 September 2008, Pages 499–504
نویسندگان
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