کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2499866 1556845 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The preventive effect of cannabinoids on reperfusion-induced ischemia of mouse kidney
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
The preventive effect of cannabinoids on reperfusion-induced ischemia of mouse kidney
چکیده انگلیسی

Artery occlusion of an organ results in ischemia. When the occlusion is opened and blood flow reinstated there will be tissue injuries identified as reperfusion-induced ischemia (RII). It has been suggested that cannabinoids (CBs) may be involved in the RII. In this study, we assessed the effect of different doses of anandamide analogs and CB receptor agonists: arachidonylcyclopropylamide (ACPA, a CB1 agonist) and JWH133 (a CB2 agonist) in the RII of the mouse kidney. Three doses (0.2, 1 and 5 mg/kg, i.p.) of ACPA or JWH133 were used 30 min prior initiation of RII. Kidneys were removed 2 and 24 h following RII and checked histologically for the grading of ischemic injury. Appropriate control groups were used as well. RII produced lesion comparable with that of ischemia. Different doses of ACPA or JWH133 prevented RII-induced lesions. It is suggestive of the CB system involvement in the kidney RII in mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Toxicologic Pathology - Volume 60, Issues 4–5, 5 August 2008, Pages 405–410
نویسندگان
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