کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2507546 1117493 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Possible molecular targets for therapeutic applications of caffeic acid phenethyl ester in inflammation and cancer
ترجمه فارسی عنوان
اهداف مولکولی احتمالی برای استفاده درمانی از فنیل اتر کافئیک اسید در التهاب و سرطان
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی

Of the various derivatives of caffeic acid, caffeic acid phenethyl ester (CAPE) is a hydrophobic, bioactive polyphenolic ester obtained from propolis extract. The objective in writing this review article was to summarize all published studies on therapeutics of CAPE in inflammation and cancer to extract direction for future research. The possible molecular targets for the action of CAPE, include various transcription factors such as nuclear factor-κB, tissue necrosis factor-α, interleukin-6, cyclooxygenase-2, Nrf2, inducible nitric oxide synthase, nuclear factor of activated T cells, hypoxia-inducible factor-1α, and signal transducers and activators of transcription. Based on the valuable data on its therapeutics in inflammation and cancer, clinical studies of CAPE should also be conducted to explore its toxicities, if any.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Food and Drug Analysis - Volume 23, Issue 1, March 2015, Pages 11–18
نویسندگان
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