کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2530981 1558894 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Roles of aldosterone in vascular calcification: An update
ترجمه فارسی عنوان
نقش آلدوسترون در کلسیفیک شدن عروق: به روز رسانی
کلمات کلیدی
آلدوسترون، کلسیفیکاسیون عروقی، مکانیسم های ژنومی، مکانیزم های غیر ژنومی، سلول های عضلانی صاف عروقی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی

Both clinical and experimental studies have demonstrated that vascular calcification (VC) is a common pathology shared in many chronic diseases such as chronic kidney disease (CKD) and diabetes. It's an independent risk factor for cardiovascular events. Since the pathogenesis of VC is complicated, current therapies have limited effects on the regression of VC. Therefore, it is urgent to investigate the potential mechanisms and find new targets for the treatment of VC. Aldosterone (Aldo), a mineralocorticoid hormone, is the metabolite of renin-angiotensin-aldosterone system (RAAS) activation, which can exert genomic and non-genomic effects on the cardiovascular system. Recent data suggests that Aldo can promote VC. Here, we summarized the roles of Aldo in the process of VC and a series of findings indicated that Aldo could act as a potentially therapeutic target for treating VC.

Oxidative stress, inflammation, apoptosis and signaling pathways are all involved in the process of vascular calcification (VC). Aldosterone (Aldo) up-regulation may promote these VC-related factors via genomic and non-genomic mechanisms, which indicates it as a potential target to treat VC.Figure optionsDownload high-quality image (119 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 786, 5 September 2016, Pages 186–193
نویسندگان
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