کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2531069 1558902 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mast cells in gastrointestinal disorders
ترجمه فارسی عنوان
سلولهای مشت در اختلالات گوارشی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی

Mast cells are constitutively found in the gastrointestinal (GI) tract. The three major physiological functions of GI mast cells comprise of – as far as we know – regulation of GI functions, namely epithelial and endothelial functions, crosstalk with the enteric nervous system, and contribution to the host defense against bacterial, viral and parasitic agents. A number of chronic GI diseases, including inflammatory bowel disease (Crohn's disease, ulcerative colitis), celiac disease, irritable bowel syndrome, and food allergies, are thought to be associated with mast cell hyperplasia and humoral activity. Clinical conditions characterized by a decrease in mast cell functionality are not known so far. In the present review, we summarize current evidence which show that human mast cells play a central role at the GI barrier, both in health and disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 778, 5 May 2016, Pages 139–145
نویسندگان
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