کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2532392 1559005 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antihyperglycemic effect of biochanin A, a soy isoflavone, on streptozotocin-diabetic rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Antihyperglycemic effect of biochanin A, a soy isoflavone, on streptozotocin-diabetic rats
چکیده انگلیسی

The study was designed to investigate the antihyperglycemic effect of biochanin A on streptozotocin-diabetic rats. Diabetes was induced in adult male albino rats of the Wistar strain, weighing 180–200 g, by administration of streptozotocin (40 mg/kg of body weight) intraperitoneally. Diabetic rats showed increase in plasma glucose and glycosylated hemoglobin and a decrease in plasma insulin and hemoglobin. Activities of gluconeogenic enzymes such as glucose 6-phosphatase, fructose 1,6-bisphosphatase increased and glucokinase, glucose 6-phosphate dehydrogenase decreased in the liver of diabetic rats along with glycogen. Oral administration of biochanin A (10 mg/kg body weight) or glibenclamide (600 μg/kg body weight) in 0.5% dimethyl sulfoxide, for 45 days, prevented the above changes and improved towards normality. In addition, protection against body weight loss of diabetic animals by biochanin A was also observed. No significant effect was observed in normal rats treated with biochanin A (10 mg/kg bodyweight). These results showed that biochanin A has potential antihyperglycemic activity at a dose of 10 mg/kg bodyweight in streptozotocin induced diabetic rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 676, Issues 1–3, 15 February 2012, Pages 89–94
نویسندگان
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