کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2533479 1559056 2010 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats
چکیده انگلیسی

Present study investigated the role of agmatine in ethanol-induced anxiolysis and withdrawal anxiety using elevated plus maze (EPM) test in rats. The anxiolytic-like effect of ethanol was potentiated by pretreatment with imidazoline I1/I2 receptor agonist agmatine (10–20 mg/kg, i.p.), imidazoline I1 receptor agonists, moxonidine (0.25 mg/kg, i.p.) and clonidine (0.015 mg/kg, i.p.), imidazoline I2 receptor agonist, 2-BFI (5 mg/kg, i.p.) as well as by the drugs known to increase endogenous agmatine levels in brain viz., l-arginine, an agmatine biosynthetic precursor (100 µg/rat, i.c.v.), ornithine decarboxylase inhibitor, DFMO (125 µg/rat, i.c.v.), diamine oxidase inhibitor, aminoguanidine (65 µg/rat, i.c.v.) and agmatinase inhibitor, arcaine (50 µg/rat, i.c.v.). Conversely, prior administration of I1 receptor antagonist, efaroxan (1 mg/kg, i.p.), I2 receptor antagonist, idazoxan (0.25 mg/kg, i.p.) and arginine decarboxylase inhibitor, d-arginine (100 µg/rat, i.c.v.) blocked the anxiolytic-like effect of ethanol. Moreover, ethanol withdrawal anxiety was markedly attenuated by agmatine (10–20 mg/kg, i.p.), moxonidine (0.25 mg/kg, i.p.), clonidine (0.015 mg/kg, i.p.), 2-BFI (5 mg/kg, i.p.), l-arginine (100 µg/rat, i.c.v.), DFMO (125 µg/rat, i.c.v.), aminoguanidine (65 µg/rat, i.c.v.) and arcaine (50 µg/rat, i.c.v.). The anti-anxiety effect of agmatine in ethanol-withdrawn rats was completely blocked by efaroxan (1 mg/kg, i.p.) and idazoxan (0.25 mg/kg, i.p.). These results suggest that agmatine and imidazoline receptor system may be implicated in ethanol-induced anxiolysis and withdrawal anxiety and strongly support further investigation of agmatine in ethanol dependence mechanism. The data also project agmatine as a potential therapeutic target in overcoming alcohol withdrawal symptoms such as anxiety.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 637, Issues 1–3, 10 July 2010, Pages 89–101
نویسندگان
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