کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2533560 | 1559059 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Agmatine prevents LPS-induced spatial memory impairment and hippocampal apoptosis Agmatine prevents LPS-induced spatial memory impairment and hippocampal apoptosis](/preview/png/2533560.png)
Neuroinflammation is associated with a number of neurodegenerative diseases. It is known that lipopolysaccharide (LPS) treatment induces neuroinflammation and memory deterioration. Agmatine, the metabolite of arginine by arginine decarboxylase, is suggested to be a neuroprotective agent. The aim of this study was to explore if agmatine can prevent LPS-induced spatial memory impairment and hippocampal apoptosis. Adult male Wistar rats (200–250 g) were trained in water maze for 4 days (3 days in hidden platform and the last day in visible platform task). Saline, LPS (250 µg/kg/ip) or (and) agmatine (5 or 10 mg/kg) were administered 4 h before every training session. LPS treatment impaired water maze place learning while agmatine co-administration prevented it. Also western blot studies revealed that LPS induces hippocampal caspase-3 activation while agmatine treatment prevented it.
Journal: European Journal of Pharmacology - Volume 634, Issues 1–3, 25 May 2010, Pages 84–88