کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2533797 | 1559065 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu®) and active metabolite
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Neuropsychiatric adverse events have been reported in influenza patients with and without exposure to oseltamivir (Tamiflu®), triggering speculation as to whether oseltamivir may be interacting with any human receptors and contributing to such neuropsychiatric events. In this study, the in vitro selectivity profile of oseltamivir prodrug and active metabolite was investigated. Both compounds lacked clinically relevant pharmacological activities on human, rodent and primate neuraminidases and on a panel of 155 other molecular targets, including those relevant for mood, cognition and behavior. Neuropsychiatric adverse events observed in influenza patients are likely a phenomenon caused by the infection rather than by oseltamivir.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 628, Issues 1–3, 25 February 2010, Pages 6–10
Journal: European Journal of Pharmacology - Volume 628, Issues 1–3, 25 February 2010, Pages 6–10
نویسندگان
Lothar Lindemann, Helmut Jacobsen, Diana Schuhbauer, Frederic Knoflach, Silvia Gatti, Joseph G. Wettstein, Hansruedi Loetscher, Tom Chu, Martin Ebeling, James C. Paulson, Eric Prinssen, Manfred Brockhaus,