کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2534722 1559098 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration
چکیده انگلیسی

It was previously shown that haloperidol, but not clozapine, induced intense rat catalepsy when co-administered with delta-9-tetrahydrocannabinol. The present study investigated whether similar alterations could be observed on striatal c-Fos immunoreactivity after administration of the same drug combinations. Western Blot and immunocytochemistry stereological analyses indicated that delta-9-tetrahydrocannabinol (0.5 mg/kg) increased striatal c-Fos immunoreactivity induced by haloperidol (0.1 mg/kg). Conversely, no significant alterations of striatal c-Fos immunoreactivity were observed after injections of clozapine (10 mg/kg) + vehicle, clozapine + delta-9-tetrahydrocannabinol or vehicle + delta-9-tetrahydrocannabinol. The present results indicate that the behavioral effects induced by delta-9-tetrahydrocannabinol in haloperidol- and clozapine-treated rats are associated with different striatal c-Fos expressions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 598, Issues 1–3, 19 November 2008, Pages 16–20
نویسندگان
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