کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2534951 1559106 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The cannabinoid CB1 receptor antagonist CE prolongs spatial memory duration in a rat delayed radial arm maze memory task
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
The cannabinoid CB1 receptor antagonist CE prolongs spatial memory duration in a rat delayed radial arm maze memory task
چکیده انگلیسی

The cannabinoid receptor system plays an integral role in learning and memory. Moreover, the cannabinoid CB1 receptor antagonist rimonabant has been found to improve performance in a variety of animal memory models. The present study tested whether a novel and potent cannabinoid CB1 receptor antagonist, CE, would prolong the duration of spatial memory. Rats were trained in a two-phase radial arm maze procedure, consisting of acquisition and retrieval tests, which were separated by an 18 h delay. CE was administered 30 min before the acquisition phase, immediately after the acquisition phase, or 30 min before the retrieval test to assess its effects on acquisition and retrieval processes. CE administered before and immediately after the acquisition phase significantly decreased the number of errors committed during the retrieval test. On the other hand, CE administered 30 min before the retrieval test had no effect on the number of errors committed. These findings demonstrate that CE improves memory by acting on consolidation, rather than retrieval, processes and further suggest that the endocannabinoid system has an important role in modulating memory duration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 590, Issues 1–3, 20 August 2008, Pages 246–249
نویسندگان
, , ,