کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2535540 | 1559123 | 2008 | 6 صفحه PDF | دانلود رایگان |

Combination therapy against human immunodeficiency virus (HIV)-infection is complicated by drug–drug interactions between antiretrovirals and also between anti-HIV drugs and drugs used to treat co-morbidity. P-glycoprotein represents one important site for drug interactions and induction of its function could reduce the effectiveness of drugs that are P-glycoprotein substrates. We therefore investigated induction of P-glycoprotein function in LS180 cells by non-nucleoside and nucleoside reverse transcriptase inhibitors (NNRTIs and NRTIs) and tenofovir as essential components of antiretroviral combination therapy. P-glycoprotein activity was increased by all NNRTIs and some NRTIs with delavirdine (5.3-fold at 100 μM) having the largest effect.
Journal: European Journal of Pharmacology - Volume 579, Issues 1–3, 28 January 2008, Pages 104–109