کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2535632 | 1559122 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Suppressive effects of leflunomide on leptin-induced TIMP-1 production involves on hepatic stellate cell proliferation and apoptosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
This manuscript revealed that following a fibrogenic stimulus of leptin in vitro, hepatic stellate cells (HSCs) underwent a complex activation process characterized by increased proliferation and excessive tissue inhibitor of metalloproteinase-1 (TIMP-1) production. Studies with special chemical inhibitors demonstrated that this process involved Janus protein tyrosine kinase (JAK)/signal transducer and activator of transcription (STAT), mitogen-activated protein kinases (MAPK), and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signal pathways. Pretreatment with A771726 (α,α,α-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide), leflunomide's metabolite, fully prevented leptin-induced TIMP-1 production in HSCs. This effect was associated with its suppression on HSC proliferation and induction of HSC apoptosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 580, Issues 1â2, 2 February 2008, Pages 63-69
Journal: European Journal of Pharmacology - Volume 580, Issues 1â2, 2 February 2008, Pages 63-69
نویسندگان
Jun Li, H.F. Si, Xiongwen Lü, Anping Guo, Hui Jiang,