کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2536230 1559150 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Methylprednisolone administration alters adenine nucleotide hydrolysis in rat blood serum
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Methylprednisolone administration alters adenine nucleotide hydrolysis in rat blood serum
چکیده انگلیسی
The effect of methylprednisolone on the hydrolysis of adenine nucleotides by rat blood serum enzymes was studied. Adult male Wistar rats were submitted to three different treatments with synthetic steroid methylprednisolone: one dose of 50 mg/kg, i.p. (acute); or oral doses of 6 mg/kg dissolved in drinking water for 15 (sub-chronic) or 30 (chronic) days. Decreased ADP hydrolysis was observed after acute and sub-chronic treatments. Furthermore, ATP, ADP and AMP hydrolysis decreased after chronic treatment. These alterations may constitute one of the mechanisms that mediate the development of some of the side effects associated with corticosteroid use.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 560, Issues 2–3, 10 April 2007, Pages 212-215
نویسندگان
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