کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2536753 | 1559164 | 2006 | 4 صفحه PDF | دانلود رایگان |
mGlu5 receptors are highly concentrated in limbic brain structures involved in motivational and emotional behaviours. This study describes the effects of 2-methyl-6-(phenylethylnyl)pyridine (MPEP; 5, 10, 15, 20 and 25 mg/kg, ip), a selective antagonist of the mGlu5 receptors, on agonistic behaviour elicited by isolation in male mice. Individually housed mice were exposed to anosmic opponents in a neutral area 30 min after drug administration. Besides other behaviours, the aggressive (threat and attack) and exploratory behaviours were evaluated during 10 min using an ethologically based analysis. MPEP produced a behavioural profile characterized by a notable decrement of offensive behaviours, accompanied by a significant increase of exploratory behaviours (nonsocial exploration and social investigation). These findings suggest a role for mGlu5 receptors in aggression modulation.
Journal: European Journal of Pharmacology - Volume 551, Issues 1–3, 3 December 2006, Pages 67–70