کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2536843 | 1559168 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Fe(III) improves antioxidant and cytoprotecting activities of mangiferin Fe(III) improves antioxidant and cytoprotecting activities of mangiferin](/preview/png/2536843.png)
Iron-induced oxidative stress has been implicated in several pathological processes. In the present work we provide evidence for the formation of a mangiferin:Fe(III) complex (2:1), shown by means of either iron-induced changes in the UV/visible spectrum of mangiferin or by reduction of the anodic current peak in the voltammogram of that compound; we demonstrate, in addition, that the ferric complex is more effective than mangiferin itself in scavenging superoxide radicals generated by pyrogallol autoxidation, as well as in protecting hepatocytes from reactive oxygen species mediated hypoxia/reoxygenation injury. Moreover, we found that the mangiferin:Fe(III) complex reacts more readily with horseradish peroxidase/H2O2 than does mangiferin by itself. We postulate that mangiferin could afford protection against iron/reactive oxygen species-mediated pathological processes by means of both iron chelating and iron-stimulated superoxide radical scavenging activity.
Journal: European Journal of Pharmacology - Volume 547, Issues 1–3, 10 October 2006, Pages 31–36