کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2537073 1559177 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ketamine enhances the expression of serine racemase and d-amino acid oxidase mRNAs in rat brain
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Ketamine enhances the expression of serine racemase and d-amino acid oxidase mRNAs in rat brain
چکیده انگلیسی

We have evaluated the effects of the acute administration of noncompetitive N-methyl-d-aspartate receptor antagonist, ketamine, on the expression of serine racemase and d-amino acid oxidase mRNAs in several brain areas of rats. The ketamine administration produced a dose-dependent and transient elevation in the levels of serine racemase and d-amino acid oxidase mRNAs in all the brain areas. These findings suggest that there is a relationship between the gene expression of the d-serine-related enzymes and the blockade of the N-methyl-d-aspartate receptors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 540, Issues 1–3, 1 July 2006, Pages 82–86
نویسندگان
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