کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2537102 1559176 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Progesterone receptor antagonist is effective in relieving neuropathic pain
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Progesterone receptor antagonist is effective in relieving neuropathic pain
چکیده انگلیسی

Injury to the spinal nerves of mice induces allodynia and hyperalgesia. Intrathecal injection of the progesterone/estrogen receptor antagonist ICI 182,780 produced antinociceptive effects. Co-administration of estrogen did not reduce but tended to enhance the antinociceptive effect of ICI 182,780. On the other hand, co-administration of progesterone dose-dependently reduced the antinociceptive effect of ICI 182,780, indicating that the antinociceptive effect is through antiprogesterone receptor activity of ICI 182,780. These results suggest that spinal progesterone receptors play an important role in neuropathic pain, and that controlling the activity of progesterone receptors may be of great importance in the treatment of neuropathic pain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 541, Issues 1–2, 10 July 2006, Pages 44–48
نویسندگان
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