کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2537249 1559184 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of a GABAB and GABAC receptor antagonist on sleep–waking cycle in the rat
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Influence of a GABAB and GABAC receptor antagonist on sleep–waking cycle in the rat
چکیده انگلیسی

This study tested the influence of CGP 36742, a both gamma-aminobutyric acidB (GABAB) and GABAC receptor antagonist, on sleep and waking. The compound was injected intraperitoneally at 1, 10, 30, 100, 300 and 500 mg/kg to rats which were recorded during 6 h. Only at 500 mg/kg, total waking was increased during third and fourth hours and total duration of recording by a specific enhancement of quiet waking (without hippocampal theta activity). Slow wave sleep was decreased at 100, 300, 500 mg/kg during the third and fourth hours, and during total recording time at 500 mg/kg. Paradoxical sleep was not affected. While it was not possible to distinguish already known GABAB and GABAC identical influence on waking and slow wave sleep, their previously shown opposite effect on paradoxical sleep seemed to nullify each other.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 535, Issues 1–3, 27 March 2006, Pages 177–181
نویسندگان
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