کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2537397 | 1559190 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effect of β2-adrenoceptor agonists on phospholipase C (beta1) signalling in human airway smooth muscle cells
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The effect of β2-adrenoceptor agonists on phospholipase C (beta1) signalling in human airway smooth muscle cells The effect of β2-adrenoceptor agonists on phospholipase C (beta1) signalling in human airway smooth muscle cells](/preview/png/2537397.png)
چکیده انگلیسی
Prolonged use of β2-adrenoceptor agonists has been associated with asthma exacerbation. Recently, phospholipase C-β1 (PLC-β1) induction in airway smooth muscle was proposed to underlie this phenomenon. We aimed to evaluate this mechanism in primary human airway smooth muscle cells. Stimulation of cells (1 μM isoprenaline or salbutamol for 2–48 h or 10− 9–10− 4M for 24 h) had no effect on PLC-β1 gene expression. 1 μM β2-adrenoceptor agonist treatment for 24 h did not alter sodium fluoride Inositol Phosphate (IP) responses, however augmented histamine IP responses (P < 0.05). Therefore, β2-adrenoceptor agonists can augment spasmogen responses in airway smooth muscle but not via a G-protein/PLC-β1 mediated mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 531, Issues 1–3, 15 February 2006, Pages 9–12
Journal: European Journal of Pharmacology - Volume 531, Issues 1–3, 15 February 2006, Pages 9–12
نویسندگان
Ian Sayers, Caroline Swan, Ian P. Hall,