کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2537414 | 1559190 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model](/preview/png/2537414.png)
چکیده انگلیسی
Closed head injury induces cerebral oxidative stress. The efficacy of a Mn (III) porphyrin catalytic antioxidant was assessed in a mouse closed head injury model. Mice were subjected to closed head injury and treated 15 min later with an i.v. bolus of vehicle or 3 mg/kg MnTE-2-PyP5+. Aconitase activity, Fluoro-Jade staining, glial fibrillary acidic protein immunoreactivity, and rotarod falling latencies were measured. Closed head injury altered all variables. MnTE-2-PyP5+ had no effect on any variable with the exception of attenuation of aconitase inactivation at 2 h post-closed head injury. In a second experiment, mice received 3 mg/kg or 6 mg/kg MnTE-2-PyP5+ or vehicle i.v. 15 min post-closed head injury. Rotarod and Morris water maze latencies were measured. Closed head injury altered performance in both tests. No statistically significant effect of MnTE-2-PyP5+ was observed. We conclude that single dose MnTE-2-PyP5+ does not alter outcome in this mouse closed head injury model.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 531, Issues 1â3, 15 February 2006, Pages 126-132
Journal: European Journal of Pharmacology - Volume 531, Issues 1â3, 15 February 2006, Pages 126-132
نویسندگان
Stephen B. Leinenweber, Huaxin Sheng, John R. Lynch, Haichen Wang, Ines BatiniÄ-Haberle, Daniel T. Laskowitz, James D. Crapo, Robert D. Pearlstein, David S. Warner,