کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2537540 1559192 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia
چکیده انگلیسی

In this study we have investigated the role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia in mice. Glutamate and GABA release changes have been monitored by in vivo microdialysis. Intra-periaqueductal grey microinjections of misoprostol, a non-selective prostaglandin receptor agonist, increased nociceptive responses in the formalin test only during the late phase. Prostanoid EP1 (L-335677), EP2 (AH 6809), EP3 (L-826266) and EP4 (L-161982) receptor antagonists prevented the nociceptive response induced by misoprostol in formalin-injected mice. Prostanoid EP1, EP2, EP3 and EP4 antagonists reduced, per se, the late hyperalgesic phase. Intra-periaqueductal grey perfusion with misoprostol increased periaqueductal grey glutamate, whereas it produced an increase followed by a decrease in GABA. Likewise, formalin increased glutamate and produced a biphasic response on GABA. When misoprostol was perfused in combination with the peripheral injection of formalin, we observed an increase of glutamate and an increase followed by a stronger decrease in GABA release. These data show that periaqueductal grey prostaglandin receptor stimulation increased formalin-induced nociceptive response in the late phase by increasing glutamate release and by producing a biphasic change in GABA release.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 530, Issues 1–2, 13 January 2006, Pages 40–47
نویسندگان
, , , , , , , , , ,