کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2537546 | 1559192 | 2006 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Influence of the post-ovariectomy time frame on the experimental anxiety and the behavioural actions of some anxiolytic agents Influence of the post-ovariectomy time frame on the experimental anxiety and the behavioural actions of some anxiolytic agents](/preview/png/2537546.png)
This study analyzes the long-term effects of ovariectomy on the basal experimental anxiety of rats and the influence of this condition on the anxiolytic properties of diazepam and the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Rats ovariectomized 3, 6 and 12 weeks previously, were tested in the burying behaviour paradigm and in an automatic activity counter. The highest values of time spent burying were observed in the 12-week group. In general, the 12-week group was more responsive to diazepam than the 3-week group, while 8-OH-DPAT showed similar effects on time spent burying, independently of how long ago the ovariectomy was done.Detection of anxiogenic-like behaviours by the shock-probe burying test in rats after chronic absence of gonadal hormones could help in the understanding of mood changes associated with human menopause.
Journal: European Journal of Pharmacology - Volume 530, Issues 1–2, 13 January 2006, Pages 88–94